Investigation of Encapsulated Selenium Nanoparticles with PLGA Polymers Against MCF-7 and HBL Cell Lines

نویسندگان

چکیده

As cancer-related deaths continue to rise, developments in nanotechnology have emerged as a feasible option for finding successful treatments targeting cancerous cells while avoiding all of the drawbacks traditional drugs. Selenium nanoparticles (SeNPs) been reported exhibit an inhibitory effect on cells. The aim present study was use drug delivery systems poly(lactic-co-glycolic acid) (PLGA) and acid-poly(ethylene glycol)-folic acid (PLGA-PEG-FA) encapsulate SeNPs investigate their antineoplastic effects against two cell line types (MCF-7 positive folate receptor HBL negative receptor) by exploiting overexpression features some cancer ensure molecules at high dosages toward targeted circumvent normal cells/tissues. were chemically synthesized characterized with dynamic light scattering (DLS) transmission electronic microscopy (TEM). cytotoxicity both nanomaterials evaluated MCF-7 using methyl thiazolyl tetrazolium (MTT) assay which showed cytotoxic lesser Additionally, apoptosis also performed acridine orange/ethidium bromide dual staining, antioxidant investigated 2,2-diphenyl-1-picrylhydrazyl (DPPH) colorimetric method potential formulations. They nonhemolytic activity human red blood This work could be considered promising pharmaceutical formulation.

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ژورنال

عنوان ژورنال: Nano Biomedicine and Engineering

سال: 2023

ISSN: ['2150-5578']

DOI: https://doi.org/10.26599/nbe.2023.9290013